Anidulafungin Pharmacokinetics and Microbial Response in Neutropenic Mice with Disseminated Candidiasis
نویسندگان
چکیده
منابع مشابه
Anidulafungin pharmacokinetics and microbial response in neutropenic mice with disseminated candidiasis.
Candidemia is often fatal, especially in patients with persistent neutropenia. New therapies are needed. We performed 24-h pharmacodynamic studies to compare the efficacies of anidulafungin, fluconazole, and amphotericin B in neutropenic mice with disseminated candidiasis caused by one of three strains of Candida glabrata. Anidulafungin produced a maximal fungal kill (E(max)) of 1.4 to 1.9 log(...
متن کاملIn vitro lymphoproliferative response and cytokine production in mice with experimental disseminated candidiasis
Objective(s): Systemic candidiasis is an infection of Candida albicans (C. albicans) causing disseminated disease and sepsis, invariably when host defenses are compromised. We investigated the histopathological changes as well as the lymphoproliferative responses and cytokine production of splenic cells after stimulation with Concanavalin A (Con A) and Pokeweed mitogen (PWM) in mice with dissem...
متن کاملin vitro lymphoproliferative response and cytokine production in mice with experimental disseminated candidiasis
objective(s): systemic candidiasis is an infection of candida albicans (c. albicans) causing disseminated disease and sepsis, invariably when host defenses are compromised. we investigated the histopathological changes as well as the lymphoproliferative responses and cytokine production of splenic cells after stimulation with concanavalin a (con a) and pokeweed mitogen (pwm) in mice with dissem...
متن کاملComparative antifungal activities and plasma pharmacokinetics of micafungin (FK463) against disseminated candidiasis and invasive pulmonary aspergillosis in persistently neutropenic rabbits.
Micafungin (FK463) is an echinocandin that demonstrates potent in vitro antifungal activities against Candida and Aspergillus species. However, little is known about its comparative antifungal activities in persistently neutropenic hosts. We therefore investigated the plasma micafungin pharmacokinetics and antifungal activities of micafungin against experimental disseminated candidiasis and inv...
متن کاملPharmacokinetics of anidulafungin in critically ill patients with candidemia/invasive candidiasis.
The pharmacokinetics of intravenous anidulafungin in adult intensive care unit (ICU) patients were assessed in this study and compared with historical data from a general patient population and healthy subjects. Intensive plasma sampling was performed over a dosing interval at steady state from 21 ICU patients with candidemia/invasive candidiasis. All patients received the recommended dosing re...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2006
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00507-06